Linear 1 3-diarylpropanoids
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 1 G
Naringenin is the predominant flavanone found in *Citrus reticulata Blanco*. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Exhibits strong anti-inflammatory activity.
- Exhibits strong antioxidant activity.
- Possesses anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Reduces plasma and liver triglycerides and cholesterol.
- Enhances hepatic fatty acid oxidation.
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 500g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 100 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that also possesses antioxidant and anti-inflammatory activities. It can improve adipocyte functions and inhibits histamine release from rat peritoneal mast cells.
- Inhibits histamine release from rat peritoneal mast cells.
- Improves adipocyte functions by enhancing adiponectin production.
- Stimulates the activity of PPARγ in cells.
- Inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated macrophages.
- Exhibits anti-allergic effects in type I allergic mice.
- Suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 5g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Apexbio Technology LLC Naringenin 480-41-1 10mM (in 1mL DMSO)
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 50 G
4'-Methoxychalcone is a compound that regulates adipocyte differentiation through PPARγ activation. It modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity.
- Regulates adipocyte differentiation via PPARγ activation.
- Modulates adipokine expression and secretion.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory markers in preadipocyte cells.
- Exhibits antiproliferative and cytotoxic activity against various human and mouse cell lines.
Medchemexpress LLC Avobenzone | 70356-09-1 | 98.0% | 10 G
Avobenzone is a dibenzoylmethane compound widely used as a filter in sunscreens for skin photoprotection in the UVA band. It is also identified as an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
- Widely used as a filter in sunscreens for UVA band skin photoprotection
- Acts as an endocrine disruptor and estrogen agonist
- Promotes adipogenesis in hBM-MSCs
- Up-regulates mRNA levels of PPARγ during adipogenesis
- Inhibits proliferative activities of human trophoblast cells
- Induces apoptosis in HTR8/SVneo cells
- Exhibits weak ERα agonism and weak AR antagonism
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 50 G
Dibenzoylmethane is a minor ingredient in licorice that activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2.
- Purity is 98.0%.
- Appearance is solid.
- Color is off-white to light yellow.
- Initial source is Plants Leguminosae Glycyrrhiza uralensis Fisch.
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 1 G
Dibenzoylmethane is a minor ingredient found in licorice that functions as a Keap1-Nrf2 activator. It is known to prevent various cancers and oxidative damage. As an analog of curcumin, it facilitates dissociation from Keap1, leading to the nuclear translocation of Nrf2.
- Activates Nrf2
- Prevents various cancers and oxidative damage
- Increases mRNA level of HO-1 in HepG2 cells
- Induces HO-1 and Nrf2 protein expression
- Increases phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells
- Reduces area and severity of necrosis and leukocyte infiltration
- Protects against CCl4-induced liver damage
eMolecules 32864-38-3 | tert-Butyl ethyl propanedioate | ChemScene | MFCD00009193 | 188.223 | C9H16O4 | 95.000 | CCOC(=O)CC(=O)OC(C)(C)C | 25g | 791179218
tert-Butyl ethyl propanedioate | ChemScene | 32864-38-3 | MFCD00009193 | 188.223 | C9H16O4 | 95.000 | CCOC(=O)CC(=O)OC(C)(C)C | 25g | 791179218
TARGETMOL CHEMICALS INC Xanthohumol 10MG
Also available in 1 mL, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Purity 99.18%